References

  1. Data on file.
  2. Agostoni A, Aygoren-Pursun E, Binkley KE, et al. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol 2004;114(3 Suppl):S51-131.
  3. Nussberger J, Cugno M, Amstutz C, Cicardi M, Pellacani A, Agostoni A. Plasma bradykinin in angio-oedema. Lancet 1998;351(9117):1693-7.
  4. Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med 2006;119(3):267-74.
  5.  Jesic R, Culafic D, Bonaci-Nikolic B. Hereditary angioedema presenting with recurrent ascites. Dig Dis Sci 2005;50(1):24-6.
  6. Branco-Ferreira M, Pedro E, Barbosa MA, Carlos AG. Ascites in hereditary angioedema. Allergy 1998;53(5):543-5.
  7. Bork K, Staubach P, Eckardt AJ, Hardt J. Symptoms, course, and complications of abdominal attacks in hereditary angioedema due to C1 inhibitor deficiency. Am J Gastroenterol 2006;101(3):619-27.
  8. Bork K, Barnstedt SE. Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema. J Am Dent Assoc 2003;134(8):1088-94.
  9. Bork K, Hardt J, Schicketanz KH, Ressel N. Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency. Arch Intern Med 2003;163(10):1229-35.
  10. Bork K, Siedlecki K, Bosch S, Schopf RE, Kreuz W. Asphyxiation by laryngeal edema in patients with hereditary angioedema. Mayo Clinic Proc 2000;75(4):349-54.
  11. Bowen T, Cicardi M, Bork K, et al. Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol 2008;100(1 Suppl 2):S30-40.
  12. Agostoni A, Cicardi M. Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients. Medicine 1992;71(4):206-15.
  13. Bracho FA. Hereditary angioedema. Curr Op Hematol 2005;12(6):493-8.
  14. Pappalardo E, Cicardi M, Duponchel C, et al. Frequent de novo mutations and exon deletions in the C1inhibitor gene of patients with angioedema. J Allergy Clin Immunol 2000;106(6):1147-54.
  15. Bork K, Barnstedt SE, Koch P, Traupe H. Hereditary angioedema with normal C1-inhibitor activity in women. Lancet 2000;356(9225):213-7.
  16. Binkley KE, Davis A, 3rd. Clinical, biochemical, and genetic characterization of a novel estrogendependent inherited form of angioedema. J Allergy Clin Immunol 2000;106(3):546-50.
  17. Dewald G, Bork K. Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor. Biochem Biophys Res Comm 2006;343(4):1286-9.
  18. Cichon S, Martin L, Hennies HC, et al. Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III. Am J Hum Genet 2006;79(6):1098-104.
  19. Hall JM. Bradykinin receptors: pharmacological properties and biological roles. Pharmacol Therap 1992;56(2):131-90.
  20. Dray A. Kinins and their receptors in hyperalgesia. Can J Physiol Pharmacol 1997;75(6):704-12.
  21. Bas M, Adams V, Suvorava T, Niehues T, Hoffmann TK, Kojda G. Nonallergic angioedema: role of bradykinin. Allergy 2007;62(8):842-56.
  22. Dray A, Perkins M. Bradykinin and inflammatory pain. Trends Neurosci 1993;16(3):99-104.
  23. Kaplan AP, Joseph K, Silverberg M. Pathways for bradykinin formation and inflammatory disease. J Allergy Clin Immunol 2002;109(2):195-209. pathophysiology of angioedema. Int Immunopharmacol 2003;3(3):311-7.
  24. Longhurst HJ, Bork K. Hereditary angioedema: causes, manifestations and treatment. Br J Hosp Med (Lond) 2006;67(12):654-7.
  25. Gompels MM, Lock RJ, Abinun M, et al. C1 inhibitor deficiency: consensus document. Clin Exp Immunol 2005;139(3):379-94.

 

News

Tue, 2012-02-14

Pharming And Transmedic Announce Distribution Agreement For Ruconest

Fri, 2012-02-10

Pharming Announces Initiation Of A Pediatric Phase II Clinical Study With Ruconest

Tue, 2012-02-07

ViroPharma Provides Update on Industrial Scale Supplement for Cinryze® (C1 Esterase Inhibitor [Human])

Mon, 2012-02-06

U.S. Senate Declares May 16, 2012 as Hereditary Angioedema Awareness Day

Tue, 2012-01-24

New Data Published On Ruconest's Effect On Blood Clotting Parameters During HAE Attacks

Fri, 2012-01-13

Health Canada Grants Priority Review Status For New Drug Submission (NDS) For Cinryze™ (C1 Inhibitor [human])

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Events

Fri, 2012-05-18 08:00 - Sun, 2012-05-20 12:00

2012 HAE Global Conference

Venue:Scandic Hotel Sydhavnen, Copenhagen, Denmark
Language:English

HAE GLOBAL CONFERENCEHAE GLOBAL CONFERENCE

HAEi is delighted to invite patients, care givers, health care professionals and industry representatives to this biannual first true global conference, where this year's theme is "Advocacy and Access".

We have prepared some VERY ATTRACTIVE conference packages for all delegates.

We expect participation from all over the world.

Read more on the 2012 HAE Global Conference website

 

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Wed, 2012-05-16 00:01 - 23:59

2012 HAE Awareness Day

Venue: All over the World!
Language: All languages

HAEDAYHAEDAYPlease have a look at www.haeday.org for more information about this first ever dedicated awareness day for hereditary angioedema (HAE). Find inspiration for national/regional events as well as an overview of planned activities on the hae day website.

..continue
Fri, 2012-03-02 08:00 - Tue, 2012-03-06 17:00

AAAAI 2012 Annual Meeting

Venue: Orange County Convention Center, Orlando, Florida, USA
Language: English

The AAAI Annual Meeting is the world's premier gathering of allergy and immunology experts. Attendees include clinicians, academicians, allied health professionals and others interested in allergic and immunologic disease.

The 2012 meeting will take place from March 2 - 6, in Orlando, Florida. We look forward to seeing you in Orlando. Read more about the conference here

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HAEi is here to help you. Therefore we have created the HAEi Community that gives you all the bells and whistles you know from other social media (such as Facebook) and even a very sophisticated Forum, where you can discuss with fellow HAE patients and care givers. The only difference is - that here your information stays safe - and will only be shared with other HAE patients and care givers. If you are a HAE patient or directly related to a HAE patient we urge you to register today - and become an important member of our community

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HAEDAYHAEDAYLook out for the first ever HAE Awareness Day on 16 May 2012


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