Diagnosing HAE is not difficult in principle; however patients frequently get a wrong diagnosis primarily because of its rarity, with many doctors not coming across a single patient with this clinical picture in their entire career. Furthermore, HAE is difficult to diagnose due to its non-specific symptoms, which often resemble those of an allergy, intestinal colic or appendicitis and can lead physicians to a wrong conclusion easily. As a result, it can take a relatively long time for HAE to be diagnosed correctly. However, while the disease remains undetected, the patient could be at risk of suffocation due to acute swelling in the larynx in a severe attack or, in the case of intestinal edema, of undergoing unnecessary endoscopy or even having their appendix removed.(2,12)


Angioedema is a common symptom and most cases of angioedema are due to an allergic reaction. As a nonallergic form of angioedema, symptoms of HAE do not typically present with urticaria and are not caused by the common triggers of an allergic response or do not respond to treatments used in histamine-mediated allergic reactions, i.e. antihistamines, glucocorticoids and epinephrine.

Ultimately, a diagnosis of HAE is confirmed by laboratory tests indicating either a reduced concentration of C1-INH and/or depressed C1-INH activity. A measure of C4 antigen concentration is also important as this parameter is decreased in both HAE types I and II. Assaying C1q concentrations is necessary to differentiate between HAE and acquired angioedema, a non –inherited form of angioedema associated with a C1-INH deficiency due to a chronic and/or serious illness.(2,11,21,25)

Diagnosis is difficult in patients who only have episodes of swelling in the intestine. Initially, further information is obtained by establishing whether anyone else in the patient’s family has had the disease (known as family history). However, only a laboratory analysis can provide final confirmation.


Mon, 2014-09-22

Dyax Corp. Highlights Recent Progress in Licensing and Funded Research Portfolio

Mon, 2014-09-22

Sobi opens the company's new North American office in Massachusetts

Mon, 2014-09-15

Dyax Announces Issuance of Two Key U.S. Patents for DX-2930

Thu, 2014-08-28

Newsletter #4/2014 just released

Wed, 2014-07-23

Recommended combination of Shire and AbbVie

Wed, 2014-07-23

Dyax Corp. Announces Publication of Scientific Data for DX-2930 in Peer-Reviewed Journals

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Thu, 2014-11-06 09:00 - Mon, 2014-11-10 16:00

ACAAI - 2014 Annual Scientific Meeting

Venue: Georgia World Congress Convention Center, Atlanta, GA, United States of America
Language: English

Plan to join your colleagues at the 71st ACAAI Annual Scientific Meeting in Atlanta, Nov. 6-10. Broaden your expertise, enhance your practice management skills and improve patient care.

For more information please visit: ACAAI Annual Meeting 2014

Fri, 2014-10-24 13:00 - Sun, 2014-10-26 12:30

International scientific conference on Expanding Boundaries of our HAE Knowledge

Venue: Bethesda Marriott, 5151 Pools Hill Road, Bethesda, MD 20814, USA
Language: English

This first international scientific meeting on HAE, sponsored by National Institutes of Health in conjunction with the US HAEA Angioedema Center at UCSD, will bring together experts in all types of angioedema, as well as clinical medicine to discuss the emerging basic science.

Read more about the conference here

Wed, 2014-10-15 12:00 - Thu, 2014-10-16 13:00

Bradykinin Symposium

Venue: Kaiserin Friedrich-Haus, Lecture Hall, Robert-Koch-Platz 7, 10115 Berlin, Germany
Language: English

Welcome to this year's Bradykinin Symposium hosted by the Charité and icare on 15-16 October 2014 in Berlin. International experts in the field of bradykinin have been invited to discuss the role of bradykinin in present and in the future.

The symposium will be complemented by the Charité/UNEV/icare/GA²LEN Angioedema School on 16-17 October 2014.

For more information please visit: Bradykinin Symposium 2014


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See the video from the 2012 HAE Global Conference in Copenhagen

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HAEDAYHAEDAYLook out for next hae day :-) on 16 May 2014