History of Hereditary AngioEdema

The history of hereditary angioedema starting with Irenäus Quincke.

The clinical picture was first described in 1882 by Heinrich Irenäus Quincke, a physician from Kiel, Germany, and was at that time called Quincke’s edema. The older literature also refers to the disease as hereditary angioneurotic edema (HANE). However, as the origin (pathogenesis) of hereditary angioedema is not influenced by neurological factors, it has gradually become known as “Hereditary AngioEdema” (HAE).

The majority of HAE cases are caused by a defect in the gene that controls a blood protein called C1-esterase inhibitor (C1-INH).

Time table

1882 - Heinrich Irenäus Quincke initially describes 'Quincke’s edema'.

1888 - HAE first described by William Osler in a 18-year old woman with episodic attacks, from five successive generations with attacks. HAE was then described as angioneurotic edema

1913 - Crowder and Crowder reported that the condition is inherited as an autosomal dominant trait (it’s located on one of the 16 pairs of chromosomes called autosomes and is inherited independent of the sex)

1963 - Donaldson and Evans showed that HAE is linked to a C1-INH deficiency

1986 - C1-INH gene localized on chromosome 11

1986 - First case of acquired angioedema (AAE) caused by anti-C1-INH antibodies described

1998 - Bradykinin appears to be main mediator of angioedema(3)

News

Thu, 2013-05-16

Dyax HAE Allies℠ Awards Program Launches on Second Annual HAE Day
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Thu, 2013-05-16

Happy hae day :-)
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Wed, 2013-04-17

Pharming And Santarus Announce Submission Of Ruconest Biologics License Application To FDA
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Tue, 2013-04-16

CSL Behring Receives European Health Authorities’ Approval of Berinert® for Short-Term Prophylaxis in Adults and Children
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Wed, 2013-04-10

A global awareness day for a life-threatening condition

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Mon, 2013-02-25

Dyax Presents DX-2930 Data at the 2013 American Academy of Allergy, Asthma and Immunology Annual Meeting
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Newsletter

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Events

Thu, 2013-05-23 12:00 - Sun, 2013-05-26 12:00

8th C1-Inhibitor Deficiency Workshop

Venue: Danubius Thermal Hotel Margitsziget, H-1133 Budapest, Hungary
Language: English

Hungary welcomes you to the 8th C1-Inhibitor Deficiency Workshop will be held in Budapest in 2013.

For more information please visit the website here

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Thu, 2013-05-16 (All day)

2013 hae day :-)

On 16 May 2013 patient organizations throughout the globe will hold events, meetings, and fundraisers to support the global awareness day hae day :-)

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Sat, 2013-05-04 09:00 - 16:00

Australasian 2013 Annual Patient Meeting

Venue: Rydges, South Bank, Brisbane, Queensland, Australia
Language: English

HAE Australasia Ltd is pleased to invite you to the patient organisation’s second patient meeting. The event will provide you with an opportunity to hear from HAE experts and to meet others who may share similar HAE experiences. It will also be a good opportunity to meet with the HAE Australasia board members and discuss how you could help spread awareness of HAE in Australia & New Zealand.

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HAE Global Community

Be part of the HAEi Community

HAEi is here to help you. Therefore we have created the HAEi Community that gives you all the bells and whistles you know from other social media (such as Facebook) and even a very sophisticated Forum, where you can discuss with fellow HAE patients and care givers. The only difference is - that here your information stays safe - and will only be shared with other HAE patients and care givers. If you are a HAE patient or directly related to a HAE patient we urge you to register today - and become an important member of our community

Help yourself and stay updated by registering already today - then you will be the first to know.....

Go to Registration page

Do you have Questions?
You can find answers on our FAQ-Page or
send us an e-mail to: info@haei.org
 or go to the contact form page

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See the video from the 2012 HAE Global Conference in Copenhagen

Click here

HAEDAYHAEDAYLook out for next hae day :-) on 16 May 2013


www.haeday.org