History of Hereditary AngioEdema

The history of hereditary angioedema starting with Irenäus Quincke.

The clinical picture was first described in 1882 by Heinrich Irenäus Quincke, a physician from Kiel, Germany, and was at that time called Quincke’s edema. The older literature also refers to the disease as hereditary angioneurotic edema (HANE). However, as the origin (pathogenesis) of hereditary angioedema is not influenced by neurological factors, it has gradually become known as “Hereditary AngioEdema” (HAE).

The majority of HAE cases are caused by a defect in the gene that controls a blood protein called C1-esterase inhibitor (C1-INH).

Time table

1882 - Heinrich Irenäus Quincke initially describes 'Quincke’s edema'.

1888 - HAE first described by William Osler in a 18-year old woman with episodic attacks, from five successive generations with attacks. HAE was then described as angioneurotic edema

1913 - Crowder and Crowder reported that the condition is inherited as an autosomal dominant trait (it’s located on one of the 16 pairs of chromosomes called autosomes and is inherited independent of the sex)

1963 - Donaldson and Evans showed that HAE is linked to a C1-INH deficiency

1986 - C1-INH gene localized on chromosome 11

1986 - First case of acquired angioedema (AAE) caused by anti-C1-INH antibodies described

1998 - Bradykinin appears to be main mediator of angioedema(3)

News

Mon, 2014-09-22

Dyax Corp. Highlights Recent Progress in Licensing and Funded Research Portfolio

Mon, 2014-09-22

Sobi opens the company's new North American office in Massachusetts

Mon, 2014-09-15

Dyax Announces Issuance of Two Key U.S. Patents for DX-2930

Thu, 2014-08-28

Newsletter #4/2014 just released

Wed, 2014-07-23

Recommended combination of Shire and AbbVie

Wed, 2014-07-23

Dyax Corp. Announces Publication of Scientific Data for DX-2930 in Peer-Reviewed Journals

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Events

Thu, 2014-11-06 09:00 - Mon, 2014-11-10 16:00

ACAAI - 2014 Annual Scientific Meeting

Venue: Georgia World Congress Convention Center, Atlanta, GA, United States of America
Language: English

Plan to join your colleagues at the 71st ACAAI Annual Scientific Meeting in Atlanta, Nov. 6-10. Broaden your expertise, enhance your practice management skills and improve patient care.

For more information please visit: ACAAI Annual Meeting 2014

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Fri, 2014-10-24 13:00 - Sun, 2014-10-26 12:30

International scientific conference on Expanding Boundaries of our HAE Knowledge

Venue: Bethesda Marriott, 5151 Pools Hill Road, Bethesda, MD 20814, USA
Language: English

This first international scientific meeting on HAE, sponsored by National Institutes of Health in conjunction with the US HAEA Angioedema Center at UCSD, will bring together experts in all types of angioedema, as well as clinical medicine to discuss the emerging basic science.

Read more about the conference here

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Wed, 2014-10-15 12:00 - Thu, 2014-10-16 13:00

Bradykinin Symposium

Venue: Kaiserin Friedrich-Haus, Lecture Hall, Robert-Koch-Platz 7, 10115 Berlin, Germany
Language: English

Welcome to this year's Bradykinin Symposium hosted by the Charité and icare on 15-16 October 2014 in Berlin. International experts in the field of bradykinin have been invited to discuss the role of bradykinin in present and in the future.

The symposium will be complemented by the Charité/UNEV/icare/GA²LEN Angioedema School on 16-17 October 2014.

For more information please visit: Bradykinin Symposium 2014

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HAE Global Community

Be part of the HAEi Community

HAEi is here to help you. Therefore we have created the HAEi Community that gives you all the bells and whistles you know from other social media (such as Facebook) and even a very sophisticated Forum, where you can discuss with fellow HAE patients and care givers. The only difference is - that here your information stays safe - and will only be shared with other HAE patients and care givers. If you are a HAE patient or directly related to a HAE patient we urge you to register today - and become an important member of our community

Help yourself and stay updated by registering already today - then you will be the first to know.....

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See the video from the 2012 HAE Global Conference in Copenhagen

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HAEDAYHAEDAYLook out for next hae day :-) on 16 May 2014


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