History of Hereditary AngioEdema

The history of hereditary angioedema starting with Irenäus Quincke.

The clinical picture was first described in 1882 by Heinrich Irenäus Quincke, a physician from Kiel, Germany, and was at that time called Quincke’s edema. The older literature also refers to the disease as hereditary angioneurotic edema (HANE). However, as the origin (pathogenesis) of hereditary angioedema is not influenced by neurological factors, it has gradually become known as “Hereditary AngioEdema” (HAE).

The majority of HAE cases are caused by a defect in the gene that controls a blood protein called C1-esterase inhibitor (C1-INH).

Time table

1882 - Heinrich Irenäus Quincke initially describes 'Quincke’s edema'.

1888 - HAE first described by William Osler in a 18-year old woman with episodic attacks, from five successive generations with attacks. HAE was then described as angioneurotic edema

1913 - Crowder and Crowder reported that the condition is inherited as an autosomal dominant trait (it’s located on one of the 16 pairs of chromosomes called autosomes and is inherited independent of the sex)

1963 - Donaldson and Evans showed that HAE is linked to a C1-INH deficiency

1986 - C1-INH gene localized on chromosome 11

1986 - First case of acquired angioedema (AAE) caused by anti-C1-INH antibodies described

1998 - Bradykinin appears to be main mediator of angioedema(3)


Thu, 2014-10-30

Pharming Reports On Financial Results For The First Nine Months Of 2014

Tue, 2014-10-28

Dyax Corp. Announces Third Quarter 2014 Financial Results

Fri, 2014-10-24

October 2014 newsletter out now

Wed, 2014-10-22

AbbVie terminates offer for Shire

Sun, 2014-10-19

Pharming And Swedish Orphan Biovitrum Amend And Extend Ruconest Distribution Agreement

Tue, 2014-10-07

BioCryst Announces Late Breaker Presentation of OPuS-1 Phase 2 Trial Results at the 23rd EADV Congress

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Fri, 2015-02-20 10:00 - Tue, 2015-02-24 16:00

AAAAI - Annual Meeting 2015

Venue: Houston, TX, United States of America
Language: English

Mark your calendars and head to Houston, Texas for the premier event in allergy/immunology. You will be able to earn CME/CE, learn about cutting-edge research and enrich your networking connections at the 2015 AAAAI Annual Meeting, February 20-24.

For more information please visit: AAAAI 2015
Sat, 2014-12-06 09:00 - Tue, 2014-12-09 15:00

WAO International Scientific Conference 2014

Venue: SulAmérica Convention Center, Av Paulo de Frontin, 1 - New City, Centro Rio de Janeiro - RJ, Brazil
Language: English

Advancing the borders of allergy: From treatment to prevention by targeting the environment, infections and the susceptible patient

We are delighted to welcome you to participate in the WAO International Scientific Conference 2014 (WISC 2014) and the XLI Annual Congress of the Brazilian Association of Allergy and Immunology (ASBAI) in Rio de Janeiro, Brazil, 6-9 December 2014.

Thu, 2014-11-06 09:00 - Mon, 2014-11-10 16:00

ACAAI - 2014 Annual Scientific Meeting

Venue: Georgia World Congress Convention Center, Atlanta, GA, United States of America
Language: English

Plan to join your colleagues at the 71st ACAAI Annual Scientific Meeting in Atlanta, Nov. 6-10. Broaden your expertise, enhance your practice management skills and improve patient care.

For more information please visit: ACAAI Annual Meeting 2014


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HAE Global Community

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HAEi is here to help you. Therefore we have created the HAEi Community that gives you all the bells and whistles you know from other social media (such as Facebook) and even a very sophisticated Forum, where you can discuss with fellow HAE patients and care givers. The only difference is - that here your information stays safe - and will only be shared with other HAE patients and care givers. If you are a HAE patient or directly related to a HAE patient we urge you to register today - and become an important member of our community

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See the video from the 2012 HAE Global Conference in Copenhagen

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HAEDAYHAEDAYLook out for next hae day :-) on 16 May 2014